Charpentier and Doudna win 2020 Nobel Prize in Chemistry
Two female scientists win the 2020 Nobel Prize in Chemistry for the discovery of powerful gene-editing tool Crispr-Cas9
- Only five women have previously won the Nobel prize for Chemistry
- The two scientists have won the award for their discovery of Crispr-Cas9
- The ground-breaking tool allows for precise changes for genetic code
Scientists Emmanuelle Charpentier, 51, and Jennifer Doudna, 56, won the 2020 Nobel Prize for Chemistry for the development of a method for genome editing.
They both worked on the discovery of Crispr/Cas9, a powerful gene-editing tool which allows researchers to make precise changes to genes.
Only five women have previously won the Nobel prize for Chemistry, despite the award first being handed out in 1901.
Crispr-Cas9 has already become one of the most widely used tools in the treatment and creation of therapeutics for hereditary diseases.
‘Emmanuelle Charpentier and Jennifer A. Doudna have discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors,’ the Royal Swedish Academy of Sciences said in a statement.
The scientists will share the 10 million Swedish crown ($1.1 million) prize.
‘This technology has had a revolutionary impact on the life sciences, is contributing to new cancer therapies and may make the dream of curing inherited diseases come true.’
More to follow…
This year’s winners of the Nobel prize for chemistry are Emmanuelle Charpentier (right) and Jennifer Doudna (left)
Scientists Emmanuelle Charpentier and Jennifer Doudna won the 2020 Nobel Prize for Chemistry
WHAT IS CRISPR-CAS9?
CRISPR-Cas9 is a tool for making precise edits in DNA, discovered in bacteria.
The acronym stands for ‘Clustered Regularly Inter-Spaced Palindromic Repeats’.
The technique involves a DNA cutting enzyme and a small tag which tells the enzyme where to cut.
The CRISPR/Cas9 technique uses tags which identify the location of the mutation, and an enzyme, which acts as tiny scissors, to cut DNA in a precise place, allowing small portions of a gene to be removed
By editing this tag, scientists are able to target the enzyme to specific regions of DNA and make precise cuts, wherever they like.
It has been used to ‘silence’ genes – effectively switching them off.
When cellular machinery repairs the DNA break, it removes a small snip of DNA.
In this way, researchers can precisely turn off specific genes in the genome.
The approach has been used previously to edit the HBB gene responsible for a condition called β-thalassaemia.
